Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark.
Contact Dermatitis. 2012 Sep;67(3):119-24. doi: 10.1111/j.1600-0536.2012.02130.x.
During the last 2 years, we have performed filaggrin genotyping in patients with eczema seen in our hand eczema clinic. We present pictures of healthy and diseased hands from individuals with filaggrin gene (FLG) mutations to describe a clinical entity of hand eczema. We show that xerosis and hyperkeratosis on the dorsal aspects of the hands and fingers, as well as palmar hyperlinearity, should alert the clinician about a possible inherited barrier abnormality of the skin resulting from FLG mutations. The series of photographs range from the hands of an individual with FLG mutations but no history of eczema, to the hands of individuals with typical and atypical filaggrin hand eczema, and finally to the hands of an individual with FLG mutations and hand eczema caused by exposure to irritants and allergens. We briefly discuss this possible subtype of hand eczema, present pathomechanisms, and indicate the signs that should alert the clinicians about a possible inherited skin barrier defect.
在过去的 2 年中，我们对手部湿疹诊所就诊的湿疹患者进行了丝聚蛋白基因分型。我们展示了带有丝聚蛋白基因突变个体的健康和患病手部的图片，以描述手部湿疹的一种临床实体。我们表明，手部和手指背侧的干燥和过度角化，以及掌部的过度线性，应该提醒临床医生注意可能由于 FLG 突变导致的皮肤遗传屏障异常。这一系列照片的范围从没有湿疹病史但带有 FLG 突变的个体的手部，到具有典型和非典型丝聚蛋白手部湿疹的个体的手部，最后到因接触刺激物和变应原而导致 FLG 突变和手部湿疹的个体的手部。我们简要讨论了这种可能的手部湿疹亚型，提出了发病机制，并指出了应该提醒临床医生注意可能存在遗传皮肤屏障缺陷的迹象。
