Pollard A E, Barr R C
Department of Biomedical Engineering, Duke University, Durham, NC 27706.
IEEE Trans Biomed Eng. 1990 Dec;37(12):1173-85. doi: 10.1109/10.64460.
The ventricular conduction system is a complicated network of specialized muscle cells responsible for the transmission of electrical activity between the atria and the ventricles of the human heart. It has been the focus of numerous electrical and anatomical studies at both the microscopic and macroscopic levels. An understanding of its behavior at both levels is considered important, because it is primarily responsible for the spread of excitation in the ventricles. Previous computer models have been very simple ones that have been primarily adjuncts to models of the ventricles. This paper describes a strategy for the construction of conduction system models which is based on real microscopic and macroscopic features, although the model still is much simpler than reality. The model contains almost 35,000 individual cylindrical elements, each of whose physical dimensions approximate unit bundles of Purkinje and atrioventricular nodal cells. The model, whose physical appearance closely resembles that of the conduction system, was generated from limited anatomical data in less than 2 min CPU time on an IBM 3090 at the Cornell National Supercomputer Facility.
心室传导系统是一个由特殊肌肉细胞组成的复杂网络，负责在人类心脏的心房和心室之间传递电活动。它一直是微观和宏观层面众多电学和解剖学研究的焦点。了解其在两个层面的行为被认为很重要，因为它主要负责兴奋在心室中的传播。以前的计算机模型非常简单，主要是心室模型的辅助。本文描述了一种构建传导系统模型的策略，该策略基于真实的微观和宏观特征，尽管该模型仍然比实际情况简单得多。该模型包含近35000个单独的圆柱形元件，每个元件的物理尺寸近似于浦肯野细胞和房室结细胞的单位束。该模型的外观与传导系统非常相似，是在康奈尔国家超级计算机设施的IBM 3090上，利用有限的解剖数据在不到2分钟的CPU时间内生成的。
