基于TiO₂的⁶⁸Ge/⁶⁸Ga发生器的长期评估及[⁶⁸Ga]DOTATOC放射性合成的优化自动化
Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis.
作者信息
Lin Mai, Ranganathan David, Mori Tetsuya, Hagooly Aviv, Rossin Raffaella, Welch Michael J, Lapi Suzanne E
机构信息
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Appl Radiat Isot. 2012 Oct;70(10):2539-44. doi: 10.1016/j.apradiso.2012.05.009. Epub 2012 Jun 19.
Interest in using (68)Ga is rapidly increasing for clinical PET applications due to its favorable imaging characteristics and increased accessibility. The focus of this study was to provide our long-term evaluations of the two TiO(2)-based (68)Ge/(68)Ga generators and develop an optimized automation strategy to synthesize [(68)Ga]DOTATOC by using HEPES as a buffer system. This data will be useful in standardizing the evaluation of (68)Ge/(68)Ga generators and automation strategies to comply with regulatory issues for clinical use.
由于其良好的成像特性和更高的可及性，用于临床正电子发射断层显像（PET）应用的（68）镓的关注度正在迅速增加。本研究的重点是对两种基于二氧化钛的（68）锗/（68）镓发生器进行长期评估，并开发一种优化的自动化策略，以使用4-（2-羟乙基）-1-哌嗪乙磺酸（HEPES）作为缓冲系统来合成[（68）镓]奥曲肽。这些数据将有助于规范（68）锗/（68）镓发生器的评估和自动化策略，以符合临床使用的监管要求。
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