美国印第安青年载脂蛋白 C-III 高密度脂蛋白的性别差异。

Sex differences in HDL ApoC-III in American Indian youth.

机构信息

Department of Pediatrics, University of Oklahoma Health Sciences Center, OU Children's Physician's Bldg, 1200 N Phillips Ave, Oklahoma City, OK, 73104, USA.

出版信息

Biol Sex Differ. 2012 Aug 16;3(1):18. doi: 10.1186/2042-6410-3-18.

DOI:10.1186/2042-6410-3-18

PMID:22898077

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3526514/

Abstract

BACKGROUND

Since American Indians are predisposed to type 2 diabetes (DM2) and associated cardiovascular risk, Cherokee boys and girls (n = 917) were studied to determine whether BMI Z (body mass index Z score) is associated with the apoC-III (apolipoprotein C-III) content of HDL (high density lipoprotein), a previously reported predictor of DM2.

METHODS

An ad hoc cross-sectional analysis was conducted on a previously studied cohort. Participants were grouped by gender-specific age groups (5 to 9, 10 to 14 and 15 to 19 years). ApoA-I (apolipoprotein A-I) and HDL apoC-III were assayed by electroimmunoassay. ApoC-III was measured in whole plasma, and in HDL to determine the molar proportion to apoA-I. General linear models were used to assess association.

RESULTS

The HDL apoC-III to apoA-I molar ratio increased by BMI Z quartile in girls aged 10-14 years (p < 0.05 for linear trend, p < 0.05 for difference in BMI Z quartile IV vs. I to III) and aged 15-19 years (p < 0.05 for trend). In boys the increase by BMI Z occurred only at ages 15-19 years (p < 0.01 for trend and for quartile difference).

CONCLUSIONS

ApoC-III showed an obesity-related increase relative to apoA-I during adolescence beginning in girls aged 10 to 14 years and in boys aged 15 to 19 years. The earlier changes in girls may alter HDL's protective properties on the β-cell and contribute to their increased risk for DM2.

摘要

背景

由于美洲印第安人易患 2 型糖尿病（DM2）和相关心血管风险，因此研究了切罗基男孩和女孩（n=917），以确定 BMI Z（体重指数 Z 评分）是否与高密度脂蛋白（HDL）中的 apoC-III（载脂蛋白 C-III）含量相关，apoC-III 是之前报道的 DM2 的预测因子。

方法

对之前研究的队列进行了专门的横断面分析。参与者按性别年龄组（5 至 9 岁、10 至 14 岁和 15 至 19 岁）分组。用免疫电泳法测定载脂蛋白 A-I（apoA-I）和 HDL apoC-III。apoC-III 在全血浆中进行测量，并在 HDL 中测量以确定与 apoA-I 的摩尔比例。使用一般线性模型评估关联。

结果

在 10-14 岁的女孩（线性趋势 p<0.05，第 IV 四分位与第 I-III 四分位的 BMI Z 四分位差异 p<0.05）和 15-19 岁的女孩（线性趋势 p<0.05）中，HDL apoC-III 与 apoA-I 的摩尔比随 BMI Z 四分位增加。在男孩中，这种增加仅发生在 15-19 岁（趋势 p<0.01，四分位差异 p<0.01）。