ABO血型与不同严重程度疟疾感染的关联。

Association of ABO groups in malaria infection of variable severity.

作者信息

Gupte Snehalata C, Patel Ankur G, Patel Tanvi G

机构信息

Parasitology Laboratory, Department of Zoology, Panjab University, Chandigarh, India.

出版信息

J Vector Borne Dis. 2012 Jun;49(2):78-81.

PMID:22898478

Abstract

BACKGROUND & OBJECTIVES: Literature reports several studies on ABO groups and malaria but a study with an adequate sample size and controls is not available. ABO groups are genetically controlled, hence, large sample size and comparison with population frequency is essential. To determine whether malaria infection with variable severity has correlation with ABO groups.

STUDY DESIGN & METHODS: Blood samples of non-transfused malaria cases were obtained from pathology laboratories and transfused malaria patients' from Blood Bank. The malaria parasites were identified by examination of thick and thin smears. Control (normal population) included 11,303 students.

RESULTS

The ABO group frequency of normal population was 'O' 32.3%, 'A' 22.2%, 'B' 36.7% and 'AB' 8.8%. The overall ABO group distribution in 8028 malaria cases was 'O' 30%, 'A' 24.6%, 'B' 35.5% and 'AB' 8.9%. 'A' group incidence was significantly higher than normal ('A' vs non-'A' = 15, df=1, p <0.001). ABO group frequencies were comparable within Plasmodium falciparum and P. vivax malaria. There was no significant difference in ABO group distribution in malaria patients having severe anemia or among transfused and nontransfused malaria cases. About 32% of P. falciparum cerebral malaria cases and 36% DIC cases were of 'A' group. Compared to 22.2% 'A' group in the population, malaria cases showed preponderance of 'A' group. Because of the small numbers statistical evaluation was not done.

CONCLUSION

'A' blood group is more susceptible to have malaria infection and risk of cerebral malaria and DIC in malaria is also more in 'A' group individuals.

摘要

背景与目的

文献报道了多项关于ABO血型与疟疾的研究，但尚无样本量充足且设有对照的研究。ABO血型受基因控制，因此，大样本量以及与人群频率进行比较至关重要。旨在确定不同严重程度的疟疾感染与ABO血型是否存在关联。

研究设计与方法

未输血疟疾病例的血样取自病理实验室，输血疟疾患者的血样取自血库。通过检查厚薄血涂片来鉴定疟原虫。对照组（正常人群）包括11303名学生。

结果

正常人群的ABO血型频率为：“O”型32.3%，“A”型22.2%，“B”型36.7%，“AB”型8.8%。8028例疟疾病例的总体ABO血型分布为：“O”型30%，“A”型24.6%，“B”型35.5%，“AB”型8.9%。“A”型发病率显著高于正常人群（“A”型与非“A”型比较，自由度df = 1，P <0.001）。在恶性疟和间日疟中，ABO血型频率具有可比性。重度贫血的疟疾病例以及输血和未输血疟疾病例的ABO血型分布无显著差异。约32%的恶性疟脑型疟病例和36%的弥散性血管内凝血（DIC）病例为“A”型。与人群中22.2%的“A”型相比，疟疾病例中“A”型占优势。由于数量较少，未进行统计学评估。