红细胞在宿主抵御恶性疟原虫疟疾中的作用：不断扩展的进化改变库。
The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations.
作者信息
Goheen Morgan M, Campino Susana, Cerami Carla
机构信息
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, The London School of Hygiene & Tropical Medicine, London, UK.
出版信息
Br J Haematol. 2017 Nov;179(4):543-556. doi: 10.1111/bjh.14886. Epub 2017 Aug 23.
Abstract
The malaria parasite has co-evolved with its human host as each organism struggles for resources and survival. The scars of this war are carried in the human genome in the form of polymorphisms that confer innate resistance to malaria. Clinical, epidemiological and genome-wide association studies have identified multiple polymorphisms in red blood cell (RBC) proteins that attenuate malaria pathogenesis. These include well-known polymorphisms in haemoglobin, intracellular enzymes, RBC channels, RBC surface markers, and proteins impacting the RBC cytoskeleton and RBC morphology. A better understanding of how changes in RBC physiology impact malaria pathogenesis may uncover new strategies to combat the disease.
摘要
疟原虫与其人类宿主共同进化，因为每种生物都在为资源和生存而斗争。这场战争的伤痕以多态性的形式存在于人类基因组中，这些多态性赋予了对疟疾的先天抵抗力。临床、流行病学和全基因组关联研究已经确定了红细胞（RBC）蛋白中的多种多态性，这些多态性可减轻疟疾发病机制。这些包括血红蛋白、细胞内酶、RBC通道、RBC表面标志物以及影响RBC细胞骨架和RBC形态的蛋白质中众所周知的多态性。更好地了解RBC生理学变化如何影响疟疾发病机制可能会揭示对抗该疾病的新策略。
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