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本文引用的文献

1
Resistance to malaria through structural variation of red blood cell invasion receptors.通过红细胞入侵受体的结构变异实现对疟疾的抗性。
Science. 2017 Jun 16;356(6343). doi: 10.1126/science.aam6393. Epub 2017 May 18.
2
β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint.β地中海贫血在旧世界的分布：从历史角度看一种古老的疾病
Mediterr J Hematol Infect Dis. 2017 Feb 20;9(1):e2017018. doi: 10.4084/MJHID.2017.018. eCollection 2017.
3
Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.葡萄糖 - 6 - 磷酸脱氢酶缺乏症对脑型疟疾和严重疟疾贫血的相反作用的特征描述
Elife. 2017 Jan 9;6:e15085. doi: 10.7554/eLife.15085.
4
Anemia Offers Stronger Protection Than Sickle Cell Trait Against the Erythrocytic Stage of Falciparum Malaria and This Protection Is Reversed by Iron Supplementation.与镰状细胞性状相比，贫血对恶性疟原虫红细胞期提供了更强的保护作用，而这种保护作用会因补充铁剂而逆转。
EBioMedicine. 2016 Dec;14:123-130. doi: 10.1016/j.ebiom.2016.11.011. Epub 2016 Nov 9.
5
Sickle Cell Trait, Rhabdomyolysis, and Mortality among U.S. Army Soldiers.美国陆军士兵中的镰状细胞性状、横纹肌溶解症与死亡率
N Engl J Med. 2016 Aug 4;375(5):435-42. doi: 10.1056/NEJMoa1516257.
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Glucose-6-Phosphate Dehydrogenase Deficiency.葡萄糖-6-磷酸脱氢酶缺乏症
Hematol Oncol Clin North Am. 2016 Apr;30(2):373-93. doi: 10.1016/j.hoc.2015.11.006.
7
Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana.加纳ABO血型对恶性疟原虫疟疾的相对易感性
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8
Quantitative phospho-proteomics reveals the Plasmodium merozoite triggers pre-invasion host kinase modification of the red cell cytoskeleton.定量磷酸化蛋白质组学揭示疟原虫裂殖子触发红细胞细胞骨架的入侵前宿主激酶修饰。
Sci Rep. 2016 Feb 2;6:19766. doi: 10.1038/srep19766.
9
"Asymptomatic" Malaria: A Chronic and Debilitating Infection That Should Be Treated.“无症状”疟疾：一种应予以治疗的慢性衰弱性感染。
PLoS Med. 2016 Jan 19;13(1):e1001942. doi: 10.1371/journal.pmed.1001942. eCollection 2016 Jan.
10
Effect of red blood cell variants on childhood malaria in Mali: a prospective cohort study.红细胞变异对马里儿童疟疾的影响：一项前瞻性队列研究。
Lancet Haematol. 2015 Apr;2(4):e140-9. doi: 10.1016/S2352-3026(15)00043-5. Epub 2015 Mar 24.

红细胞在宿主抵御恶性疟原虫疟疾中的作用：不断扩展的进化改变库。

The role of the red blood cell in host defence against falciparum malaria: an expanding repertoire of evolutionary alterations.

作者信息

Goheen Morgan M, Campino Susana, Cerami Carla

机构信息

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, The London School of Hygiene & Tropical Medicine, London, UK.

出版信息

Br J Haematol. 2017 Nov;179(4):543-556. doi: 10.1111/bjh.14886. Epub 2017 Aug 23.

DOI:10.1111/bjh.14886
PMID:28832963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5922454/
Abstract

The malaria parasite has co-evolved with its human host as each organism struggles for resources and survival. The scars of this war are carried in the human genome in the form of polymorphisms that confer innate resistance to malaria. Clinical, epidemiological and genome-wide association studies have identified multiple polymorphisms in red blood cell (RBC) proteins that attenuate malaria pathogenesis. These include well-known polymorphisms in haemoglobin, intracellular enzymes, RBC channels, RBC surface markers, and proteins impacting the RBC cytoskeleton and RBC morphology. A better understanding of how changes in RBC physiology impact malaria pathogenesis may uncover new strategies to combat the disease.

摘要

疟原虫与其人类宿主共同进化，因为每种生物都在为资源和生存而斗争。这场战争的伤痕以多态性的形式存在于人类基因组中，这些多态性赋予了对疟疾的先天抵抗力。临床、流行病学和全基因组关联研究已经确定了红细胞（RBC）蛋白中的多种多态性，这些多态性可减轻疟疾发病机制。这些包括血红蛋白、细胞内酶、RBC通道、RBC表面标志物以及影响RBC细胞骨架和RBC形态的蛋白质中众所周知的多态性。更好地了解RBC生理学变化如何影响疟疾发病机制可能会揭示对抗该疾病的新策略。