逆转录病毒癌基因：历史概述。
Retroviral oncogenes: a historical primer.
机构信息
The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
Nat Rev Cancer. 2012 Sep;12(9):639-48. doi: 10.1038/nrc3320. Epub 2012 Aug 17.
Abstract
Retroviruses are the original source of oncogenes. The discovery and characterization of these genes was made possible by the introduction of quantitative cell biological and molecular techniques for the study of tumour viruses. Key features of all retroviral oncogenes were first identified in src, the oncogene of Rous sarcoma virus. These include non-involvement in viral replication, coding for a single protein and cellular origin. The MYC, RAS and ERBB oncogenes quickly followed SRC, and these together with PI3K are now recognized as crucial driving forces in human cancer.
摘要
逆转录病毒是癌基因的原始来源。这些基因的发现和特征描述得益于定量细胞生物学和分子技术的引入，这些技术可用于研究肿瘤病毒。所有逆转录病毒癌基因的关键特征最初都是在 Rous 肉瘤病毒的癌基因 src 中鉴定出来的。这些特征包括不参与病毒复制、编码单个蛋白质和细胞起源。随后 MYC、RAS 和 ERBB 癌基因迅速跟进了 SRC，这些基因与 PI3K 一起，现在被认为是人类癌症的关键驱动因素。
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