Université de Rennes 1, UMR 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM, UFR Sciences Biologiques et Pharmaceutiques, 2 avenue du Prof Léon Bernard, F-35043 Rennes Cedex, France.
Org Biomol Chem. 2012 Oct 7;10(37):7453-6. doi: 10.1039/c2ob26033f. Epub 2012 Aug 16.
The lack of stability of the 9-membered enediynes not associated with an apoprotein may explain the low number of isolated natural compounds containing this core. To overcome such a problem, particular attention should be paid during the process of extraction and isolation of secondary metabolites, especially from microorganisms such as actinomycetes in order to identify the non-cycloaromatized derivatives.
与脱辅蛋白非关联的 9 元烯二炔的不稳定性可能解释了含有这种核心的分离天然化合物数量较少的原因。为了解决这个问题，在提取和分离次生代谢产物的过程中，特别是从放线菌等微生物中，应特别注意识别非环芳构化衍生物。
