Wnt 结构架构与功能演变。
Structural architecture and functional evolution of Wnts.
机构信息
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
出版信息
Dev Cell. 2012 Aug 14;23(2):227-32. doi: 10.1016/j.devcel.2012.07.011.
Abstract
The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.
摘要
Wnt 形态发生素与其卷曲受体外显域结合的晶体结构为深入了解这种复杂折叠的进化起源提供了线索，并解释了为什么 Wnt 既利用脂质介导的接触又利用蛋白介导的接触来与卷曲受体结合。
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