Reisser C, Goerttler K, Feichter G, Maier H
Universitäts-HNO-Klinik Heidelberg.
HNO. 1990 Nov;38(11):412-6.
In this study the validity and specificity of fine needle aspiration biopsy in cervical lymph node disease was examined. From 1983 to 1989, 495 outpatients were subjected to fine needle aspiration biopsies. One hundred and seven of the smears were not usable due to insufficient material. Tumour cells were found in 124 of the remaining 388 smears. In 117 of these cases the cytological findings were confirmed by later histology or clinical history. In the 7 remaining cases the cytological diagnosis of malignant lymphoma was disproved by histology. There were 38 (14%) false-negative diagnoses in 264 smears without tumour cells. In most of these cases the patient had undergone prior surgical or radiation therapy or had a malignant lymphoma. In spite of this relatively high number of false-negative results fine needle aspiration biopsy is helpful in the diagnosis of cervical lymph node disease. It must be emphasized that it is a screening method only: in the diagnosis of a tumour the method can only confirm and never disprove the clinical suspicion of malignancy.
在本研究中，对细针穿刺活检在颈部淋巴结疾病中的有效性和特异性进行了检查。1983年至1989年期间，495例门诊患者接受了细针穿刺活检。由于取材不足，107份涂片无法使用。在其余388份涂片中，有124份发现了肿瘤细胞。在其中117例中，细胞学检查结果随后被组织学或临床病史所证实。在其余7例中，恶性淋巴瘤的细胞学诊断被组织学否定。在264份无肿瘤细胞的涂片中，有38例（14%）出现假阴性诊断。在大多数这些病例中，患者曾接受过手术或放疗，或患有恶性淋巴瘤。尽管假阴性结果数量相对较高，但细针穿刺活检对颈部淋巴结疾病的诊断仍有帮助。必须强调的是，它只是一种筛查方法：在肿瘤诊断中，该方法只能证实而绝不能排除临床对恶性肿瘤的怀疑。
