Ramakrishna Y, Goda H, Baliga M S, Munshi A K
Dept. of Pedodontics and Preventive Dentistry, K. D. Dental College and Hospital, Mathura, U.P., India.
J Clin Pediatr Dent. 2011 Fall;36(1):55-63. doi: 10.17796/jcpd.36.1.f485870h90174311.
The association between the oral microbiota and oral diseases is well established. Various antimicrobial agents including antibiotics are commercially available against oral pathogenic bacteria. For the reasons of antibiotic resistance, their adverse effects and financial considerations in the developing countries, there is a need for alternate preventive and curative treatment options that are also safe, effective and economical. Traditional medicines have been used since ancient times for the treatment of oral diseases including dental caries, periodontal diseases that affect the majority of the population and can affect a person's overall health. Natural phytochemicals are certain organic components isolated from plants and some of these extracts are considered to be beneficial to health. They serve as antioxidants, enhance immune response, provide protection against oral cancer and other diseases and also repair DNA damage caused by smoking and other toxic exposure, and detoxify carcinogens. The natural products derived from medicinal plants have proven to be an abundant source of biologically active compounds, many of which have been the basis for the development of new lead chemicals for pharmaceuticals. They are considered to be good alternatives to synthetic chemicals. This article presents a review of natural alternatives derived from plants and plant products that can serve as a prevention and treatment option against cariogenic bacteria.
口腔微生物群与口腔疾病之间的关联已得到充分证实。包括抗生素在内的各种抗菌剂在市场上可用于对抗口腔病原菌。由于抗生素耐药性、其副作用以及发展中国家的经济考量，需要有安全、有效且经济的替代预防和治疗方案。传统药物自古以来就被用于治疗口腔疾病，包括影响大多数人群且会影响个人整体健康的龋齿、牙周疾病。天然植物化学物质是从植物中分离出的某些有机成分，其中一些提取物被认为对健康有益。它们可作为抗氧化剂，增强免疫反应，预防口腔癌和其他疾病，还能修复由吸烟和其他有毒暴露导致的DNA损伤，并使致癌物解毒。源自药用植物的天然产物已被证明是生物活性化合物的丰富来源，其中许多已成为开发新型药物先导化合物的基础。它们被认为是合成化学品的良好替代品。本文综述了源自植物和植物产品的天然替代品，这些替代品可作为预防和治疗致龋菌的选择。
