Mansour-Ghanaei Fariborz, Joukar Farahnaz, Baghaei Seyed Mohammad, Yousefi-Mashhoor Mahmood, Naghipour Mohammad Reza, Sanaei Omid, Naghdipour Misa, Shafighnia Shora, Atrkar-Roushan Zahra
Division of Gastroenterology and Hepatology, Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University (Medical Sciences), Rasht, Iran.
Asian Pac J Cancer Prev. 2012;13(5):1779-82. doi: 10.7314/apjcp.2012.13.5.1779.
In patients with gastric cancer, the most frequently reported family history of cancer also involves the stomach. The aim of this study was to assess the presence of gastric precancerous lesions in first-degree relatives of patients with gastric cancer and to compare the obtained results with those of individuals with no such family history.
Between 2007 and 2009, 503 consecutive persons more than 30 years old were enrolled in the study covering siblings, parents or children of patients with confirmed adenocarcinoma of stomach. The control group was made up of 592 patients who were synchronously undergoing upper gastrointestinal endoscopy for evaluation of dyspepsia without gastric cancer or any family history. All subjects were endoscopically examined.
The overall prevalence of Helicobacter pylori was 77.7% in the cancer relatives and in 75.7% in the control group. Chronic gastritis was found in 90.4% vs. 81.1% (P<0.001). Regarding histological findings, 37(7.4%) of the study group had atrophy vs. 12(1.7%) in the control group (P<0.001), while no difference was observed for intestinal metaplasia (20.3%vs. 21.6%, P=0.58). Dysplasia were shown in 4% of cancer relatives but only 0.4% of the control group (P<0.001). There was no gender specificity.
Findings of our study point to great importance of screening in relatives of gastric cancer patients in Iran.
在胃癌患者中，最常报告的癌症家族史也涉及胃部。本研究的目的是评估胃癌患者一级亲属中胃癌前病变的存在情况，并将所得结果与无此类家族史的个体进行比较。
2007年至2009年期间，连续纳入503名30岁以上的人员，包括确诊为胃腺癌患者的兄弟姐妹、父母或子女。对照组由592名因消化不良同步接受上消化道内镜检查但无胃癌或任何家族史的患者组成。所有受试者均接受内镜检查。
癌症亲属中幽门螺杆菌的总体患病率为77.7%，对照组为75.7%。发现慢性胃炎的比例分别为90.4%和81.1%（P<0.001）。关于组织学发现，研究组中有37人（7.4%）有萎缩，而对照组为12人（1.7%）（P<0.001），而肠化生方面未观察到差异（20.3%对21.6%，P=0.58）。发育异常在癌症亲属中占4%，而对照组仅为0.4%（P<0.001）。无性别特异性。
我们的研究结果表明在伊朗对胃癌患者亲属进行筛查非常重要。
