Newbold K M, Howie A J
Department of Pathology, University of Birmingham, U.K.
J Pathol. 1990 Dec;162(4):329-32. doi: 10.1002/path.1711620409.
A method of measurement of glomerular cross-sectional area was applied to 267 renal biopsies from 19 groups of patients with well-defined pathological and clinical conditions. There was a correlation between the mean glomerular area for each group and the percentage of global sclerosis in each group. A few groups had glomeruli that were larger than would be expected from their percentage of global sclerosis, probably due to cellular proliferation and/or infiltration. A few groups had glomeruli that were smaller than would be expected from their percentage of global sclerosis, probably due to ischaemic shrinkage. These observations indicate that as well as the known influence of body size on the glomerular area, the number of functioning glomeruli in the body has an important effect on the glomerular area.
一种测量肾小球横截面积的方法应用于来自19组具有明确病理和临床状况患者的267份肾活检样本。每组的平均肾小球面积与每组的球性硬化百分比之间存在相关性。少数组的肾小球大于根据其球性硬化百分比所预期的大小，可能是由于细胞增殖和/或浸润。少数组的肾小球小于根据其球性硬化百分比所预期的大小，可能是由于缺血性萎缩。这些观察结果表明，除了已知的体型对肾小球面积的影响外，体内有功能的肾小球数量对肾小球面积也有重要影响。
