Poudel Bibek, Mittal Ankush, Shrestha Rojeet, Nepal Ashwini Kumar, Shukla Pramod Shanker
Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal.
Asian Pac J Cancer Prev. 2012;13(5):2149-52. doi: 10.7314/apjcp.2012.13.5.2149.
This study was performed to assess prostate biomarkers with reference to body mass index and duration of prostate cancer.
A hospital based retrospective study was undertaken using data retrieved from the register maintained in the Department of Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal between 1st January, 2009 and 28th February, 2012. Biomarkers studied were prostate specific antigen (PSA), acid phosphatase (ACP) and prostatic acid phosphatase (PAP), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (γGT). Demographic data including age, duration of disease, body weight, height and body mass index (BMI) were also collected. Duration of disease was categorized into three groups: <1 year, 1-2 years and >2 years. Similarly, BMI (kg/m2) was categorized into three groups: <23 kg/m2, 23-25 kg/ m2 and >25 kg/m2. Descriptive statistics and testing of hypothesis were used for the analysis using EPI INFO and SPSS 16 software.
Out of 57 prostate cancers, serum level of PSA, ACP and PAP were increased above the cut-off point in 50 (87.5%), 30 (52.63%) and 40 (70.18%) respectively. Serum levels of PSA, ACP and PAP significantly declined with the duration of disease after diagnosis. We observed significant and inverse relation between PSA and BMI. Similar non-signficiant tendencies were apparent for ACP and PAP.
Decreasing levels of prostate biomarkers were found with the duration of prostate cancer and with increased BMI. Out of prostate biomarkers, PSA was found to be significantly decreased with the duration of disease and BMI.
本研究旨在参照体重指数和前列腺癌病程评估前列腺生物标志物。
采用基于医院的回顾性研究，数据取自2009年1月1日至2012年2月28日尼泊尔博卡拉马尼帕尔教学医院生物化学科保存的登记册。所研究的生物标志物包括前列腺特异性抗原（PSA）、酸性磷酸酶（ACP）和前列腺酸性磷酸酶（PAP）、碱性磷酸酶（ALP）和γ-谷氨酰转肽酶（γGT）。还收集了包括年龄、病程、体重、身高和体重指数（BMI）在内的人口统计学数据。病程分为三组：<1年、1 - 2年和>2年。同样，BMI（kg/m²）分为三组：<23 kg/m²、23 - 25 kg/m²和>25 kg/m²。使用EPI INFO和SPSS 16软件进行描述性统计和假设检验以进行分析。
在57例前列腺癌患者中，PSA、ACP和PAP的血清水平分别有50例（87.5%）、30例（52.63%）和40例（70.18%）高于临界值。诊断后，PSA、ACP和PAP的血清水平随病程显著下降。我们观察到PSA与BMI之间存在显著的负相关关系。ACP和PAP也有类似的非显著趋势。
发现前列腺生物标志物水平随前列腺癌病程延长和BMI升高而降低。在前列腺生物标志物中，PSA随病程和BMI显著降低。
