Campbell Family Institute for Cancer Research/Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
Ann N Y Acad Sci. 2012 Aug;1266:68-71. doi: 10.1111/j.1749-6632.2012.06577.x.
Through improvements in xenograft assay methods and in the identification of novel cell surface markers, significant progress has been made in our understanding of the human hematopoietic stem and progenitor hierarchy. The isolation of clonally pure populations of stem cells and early progenitors opens the way to carry out gene expression profiling studies to uncover the molecular regulators of each developmental step and to gain insight into the process of lineage commitment in human hematopoiesis.
通过改进异种移植检测方法和鉴定新的细胞表面标记物，我们对人类造血干/祖细胞的层次结构有了更深入的了解。克隆纯的干细胞和早期祖细胞的分离为进行基因表达谱研究开辟了道路，以揭示每个发育步骤的分子调控因子，并深入了解人类造血谱系分化的过程。
