Kato Y, Murakami M, Hoshino Y, Mori T, Maruo K, Hirata A, Nakagawa T L D R, Yanai T, Sakai H
Laboratory of Veterinary Pathology, Life Science Research Centre, Gifu University, 1-1 Yanagido, Gifu, Japan.
J Comp Pathol. 2013 Feb;148(2-3):188-96. doi: 10.1016/j.jcpa.2012.06.009. Epub 2012 Aug 16.
The immunohistochemical expression of the class A macrophage scavenger receptor CD204, was investigated in 50 canine histiocytic sarcomas (HSs) and compared with that of CD18, CD163, CD11d and class II molecules of the major histocompatibility complex (MHC). Expression of CD204 was also determined in 81 canine round cell tumours and pleomorphic sarcomas including T- and B-cell lymphomas, mast cell tumours, extramedullary plasmacytomas, cutaneous histiocytomas, transmissible venereal tumours, pigmented or amelanotic melanomas, poorly differentiated haemangiosarcomas and rhabdomyosarcomas. All of the 50 HSs expressed CD204, CD18 and MHC class II; 27 were positive for CD163 and seven expressed CD11d. All of the round cell tumours, except for one grade III mast cell tumour, were negative for CD204; however, they showed varying immunoreactivity patterns for CD18 and MHC class II. None of the pleomorphic sarcomas were immunoreactive for CD204. CD204 would appear to be a useful marker for canine HS.
研究了50例犬组织细胞肉瘤（HS）中A类巨噬细胞清道夫受体CD204的免疫组化表达，并与CD18、CD163、CD11d以及主要组织相容性复合体（MHC）的II类分子进行比较。还测定了81例犬圆形细胞瘤和多形性肉瘤中CD204的表达，这些肿瘤包括T细胞和B细胞淋巴瘤、肥大细胞瘤、髓外浆细胞瘤、皮肤组织细胞瘤、传染性性病肿瘤、色素性或无色素性黑色素瘤、低分化血管肉瘤和横纹肌肉瘤。50例HS均表达CD204、CD18和MHC II类分子；27例CD163呈阳性，7例表达CD11d。除1例III级肥大细胞瘤外，所有圆形细胞瘤CD204均为阴性；然而，它们对CD18和MHC II类分子显示出不同的免疫反应模式。多形性肉瘤中没有一例对CD204呈免疫反应性。CD204似乎是犬HS的一个有用标志物。
