Griffith University School of Medicine, Gold Coast Campus, Griffith University, Southport, QLD 4222, Australia.
Diagn Pathol. 2012 Aug 18;7:106. doi: 10.1186/1746-1596-7-106.
The current paper describes a case of prostatic adenocarcinoma metastatic to the skin presenting as an extrammamary Paget's disease, a very rare and poorly characterised morphological entity. We report a case of prostatic carcinoma metastatic to skin showing a pattern of extramammary Paget's disease which has not been clearly illustrated in the literature Case presentation: A 63 year-old man with prostatic adenocarcinoma developed cutaneous metastases after 16 years. The inguinal metastases were sessile and 'keratotic.' The tumour displayed solid, glandular areas as well as a polypoid region suggestive of extramammary Paget's disease were identified.
We review the diagnostic criteria that have led to the correct histopathological diagnosis in this case. A differential diagnosis of the pagetoid spread in the skin and various forms of cutaneous metastases determined by a prostatic adenocarcinoma as well as the role of immunohistochemistry in establishing the prostatic origin are presented in the context of this case. Although, morphologically the cells presented in the skin deposits were not characteristic for adenocarcinoma of prostate, immunohistochemistry for PSA and PSAP suggested a prostatic origin.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1395450057455276.
本论文描述了一例前列腺腺癌转移至皮肤，表现为罕见且特征不明显的乳腺外派杰病（Paget's disease）。我们报告了一例前列腺癌转移至皮肤，表现为乳腺外派杰病模式，该模式在文献中尚未明确说明。
一名 63 岁男性患有前列腺腺癌，16 年后出现皮肤转移。腹股沟转移灶呈无蒂状和角化状。肿瘤显示出实性、腺性区域，以及提示乳腺外派杰病的息肉状区域。
我们回顾了导致该病例正确组织病理学诊断的诊断标准。在该病例中，对皮肤中派杰样播散和各种形式的皮肤转移的鉴别诊断进行了讨论，包括由前列腺腺癌引起的皮肤转移，并介绍了免疫组织化学在确定前列腺来源中的作用。尽管皮肤沉积物中的细胞在形态上不典型，但免疫组织化学检测 PSA 和 PSAP 提示前列腺来源。
本文的虚拟幻灯片可在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/1395450057455276。
