Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
Cell. 2012 Aug 17;150(4):669-70. doi: 10.1016/j.cell.2012.07.020.
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.
Hippo-YAP 通路通过调节细胞增殖和凋亡来控制器官大小。于等人现在揭示了 G 蛋白偶联受体在转录共激活因子 YAP/TAZ 的上游起作用。这项研究加强了肌动蛋白细胞骨架和 Hippo 通路活性之间的联系，并确定了一类 YAP/TAZ 活性的分泌细胞外调节剂。
Zotero 插件