Hippo 信号通路远距离传递。
Hippo signaling goes long range.
机构信息
Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA.
出版信息
Cell. 2012 Aug 17;150(4):669-70. doi: 10.1016/j.cell.2012.07.020.
PMID:22901800
Abstract
The Hippo-YAP pathway regulates organ size by modulating cell proliferation and apoptosis. Yu et al. now reveal that G-protein-coupled receptors act upstream of the transcriptional coactivators YAP/TAZ. This study reinforces the connection between the actin cytoskeleton and Hippo pathway activity and identifies a class of secreted extracellular regulators of YAP/TAZ activity.
摘要
Hippo-YAP 通路通过调节细胞增殖和凋亡来控制器官大小。于等人现在揭示了 G 蛋白偶联受体在转录共激活因子 YAP/TAZ 的上游起作用。这项研究加强了肌动蛋白细胞骨架和 Hippo 通路活性之间的联系，并确定了一类 YAP/TAZ 活性的分泌细胞外调节剂。
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