Division of Rheumatology and Interstitial Lung Disease Program, National Jewish Health, Denver, CO, USA.
Lancet. 2012 Aug 18;380(9842):689-98. doi: 10.1016/S0140-6736(12)61079-4.
Some of the most pressing challenges associated with interstitial lung disease (ILD) are how best to define, diagnose, and treat connective tissue disease-associated ILD (CTD-ILD)--disorders with potentially substantial morbidity and mortality. In this focused review, we address aspects of prognosis for CTD-ILD and what indices might predict outcome, together with lessons that can be learnt from clinical trials of systemic sclerosis-associated ILD and idiopathic pulmonary fibrosis and how these lessons might be applied to future studies of CTD-ILD.
一些与间质性肺病（ILD）相关的最紧迫的挑战是如何最好地定义、诊断和治疗结缔组织病相关性ILD（CTD-ILD）——这些疾病具有潜在的高发病率和死亡率。在本次重点综述中，我们探讨了 CTD-ILD 的预后方面以及哪些指标可能预测结局，同时还探讨了从系统性硬化症相关性ILD 和特发性肺纤维化的临床试验中吸取的经验教训，以及这些经验教训如何应用于未来的 CTD-ILD 研究。
