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[BRCA1：非小细胞肺癌化疗和放疗的一种新的预测性基因组标志物]

[BRCA1: a new predictive genomic marker for chemotherapy and radiotherapy of non-small cell lung cancer].

作者信息

Li Min, Fan Saijun

机构信息

School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.

出版信息

Zhongguo Fei Ai Za Zhi. 2012 Aug;15(8):481-90. doi: 10.3779/j.issn.1009-3419.2012.08.06.

DOI:10.3779/j.issn.1009-3419.2012.08.06
PMID:22901997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5999957/
Abstract

Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors worldwide. Chemotherapy and radiotherapy are the main methods in therapy of NSCLC. The identification and characterization of predictive markers of radio- and chemo-sensitivity will be beneficial with customized treatment of NSCLC patients. This article will review the evidence regarding breast cancer susceptibility gene 1 (BRCA1) as a new predictive marker for chemotherapy and radiotherapy of NSCLC.

摘要

非小细胞肺癌（NSCLC）是全球最常见的恶性肿瘤之一。化疗和放疗是NSCLC治疗的主要方法。识别和表征放射敏感性和化疗敏感性的预测标志物将有助于对NSCLC患者进行个体化治疗。本文将综述关于乳腺癌易感基因1（BRCA1）作为NSCLC化疗和放疗新预测标志物的证据。

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2
The role of BRCA1 in non-small cell lung cancer.BRCA1在非小细胞肺癌中的作用。
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本文引用的文献

1
Combined analysis of mRNA expression of ERCC1, BAG-1, BRCA1, RRM1 and TUBB3 to predict prognosis in patients with non-small cell lung cancer who received adjuvant chemotherapy.ERCC1、BAG-1、BRCA1、RRM1 和 TUBB3 的 mRNA 表达联合分析预测接受辅助化疗的非小细胞肺癌患者的预后。
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2
ERCC1 and BRAC1 mRNA expression levels in the primary tumor could predict the effectiveness of the second-line cisplatin-based chemotherapy in pretreated patients with metastatic non-small cell lung cancer.原发肿瘤中 ERCC1 和 BRAC1 mRNA 表达水平可预测经治转移性非小细胞肺癌患者二线含铂化疗的疗效。
J Thorac Oncol. 2012 Apr;7(4):663-71. doi: 10.1097/JTO.0b013e318244bdd4.
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[EGFR gene copy number, ERCC1 and BRCA1 protein expression and their relationship in non-small cell lung cancer].[表皮生长因子受体（EGFR）基因拷贝数、切除修复交叉互补基因1（ERCC1）和乳腺癌1号基因（BRCA1）蛋白表达及其在非小细胞肺癌中的关系]
Zhonghua Zhong Liu Za Zhi. 2011 Jul;33(7):508-12.
4
RRM1 expression and clinical outcome of gemcitabine-containing chemotherapy for advanced non-small-cell lung cancer: a meta-analysis.RRM1 表达与吉西他滨为基础的化疗治疗晚期非小细胞肺癌的临床结局：一项荟萃分析。
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Zhonghua Nei Ke Za Zhi. 2011 Jun;50(6):469-73. doi: 10.3760/cma.j.issn.0578-142.2011.06.006.
6
[Relationship between the protein expression of ERCC1, BRCA, β-tubulin and K-ras and the efficacy and prognosis in advanced non-small cell lung cancer].[ERCC1、BRCA、β-微管蛋白和K-ras蛋白表达与晚期非小细胞肺癌疗效及预后的关系]
Zhonghua Zhong Liu Za Zhi. 2011 Mar;33(3):212-6.
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.2008 年全球癌症负担估计值：GLOBOCAN 2008。
Int J Cancer. 2010 Dec 15;127(12):2893-917. doi: 10.1002/ijc.25516.
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Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
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The role of BRCA1 in DNA damage response.BRCA1 在 DNA 损伤反应中的作用。
Protein Cell. 2010 Feb;1(2):117-23. doi: 10.1007/s13238-010-0010-5.
10
Correlation of BRCA1, TXR1 and TSP1 mRNA expression with treatment outcome to docetaxel-based first-line chemotherapy in patients with advanced/metastatic non-small-cell lung cancer.BRCA1、TXR1 和 TSP1 mRNA 表达与晚期/转移性非小细胞肺癌患者接受基于多西紫杉醇的一线化疗治疗结局的相关性。
Br J Cancer. 2011 Jan 18;104(2):316-23. doi: 10.1038/sj.bjc.6606027. Epub 2010 Dec 14.