[BRCA1：非小细胞肺癌化疗和放疗的一种新的预测性基因组标志物]
[BRCA1: a new predictive genomic marker for chemotherapy and radiotherapy of non-small cell lung cancer].
作者信息
Li Min, Fan Saijun
机构信息
School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2012 Aug;15(8):481-90. doi: 10.3779/j.issn.1009-3419.2012.08.06.
Abstract
Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors worldwide. Chemotherapy and radiotherapy are the main methods in therapy of NSCLC. The identification and characterization of predictive markers of radio- and chemo-sensitivity will be beneficial with customized treatment of NSCLC patients. This article will review the evidence regarding breast cancer susceptibility gene 1 (BRCA1) as a new predictive marker for chemotherapy and radiotherapy of NSCLC.
摘要
非小细胞肺癌（NSCLC）是全球最常见的恶性肿瘤之一。化疗和放疗是NSCLC治疗的主要方法。识别和表征放射敏感性和化疗敏感性的预测标志物将有助于对NSCLC患者进行个体化治疗。本文将综述关于乳腺癌易感基因1（BRCA1）作为NSCLC化疗和放疗新预测标志物的证据。
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