Department of Research and Education, Guizhou Province People's Hospital, Guiyang, China.
Immunol Lett. 2012 Nov-Dec;148(1):53-8. doi: 10.1016/j.imlet.2012.08.001. Epub 2012 Aug 10.
Many means in inbred rodent models promoted long-term graft survival or donor-specific tolerance, but less so in nonhuman primates, outbred rodents or human patients. A diverse repertoire of memory T cells, derived from heterologous immunity or prior to exposure to alloantigen, has been believed to be an important part of this barrier. Memory T cells have a unique capacity to generate effector functions quickly upon re-exposure to antigen, and this capacity is achieved by reduced activation thresholds, and expressed high level trafficking and adhesion molecules, which is likely responsible for their exhibiting differential susceptibility to immune therapeutics compared with naïve T cells. This review outlines recent progress on characteristics of memory T cells and focuses on these potential therapies targeting memory T cells which are likely to ameliorate allograft rejection by inducing transplant tolerance.
许多同种系啮齿动物模型中的方法促进了长期移植物存活或供体特异性耐受，但在非人类灵长类动物、杂交啮齿动物或人类患者中效果较差。人们认为，来自异源免疫或在接触同种异体抗原之前产生的记忆 T 细胞的多样化 repertoire 是这种障碍的重要组成部分。记忆 T 细胞具有在再次接触抗原时快速产生效应功能的独特能力，这种能力是通过降低激活阈值和表达高水平的迁移和粘附分子来实现的，这可能是它们与幼稚 T 细胞相比表现出对免疫治疗药物不同敏感性的原因。本综述概述了记忆 T 细胞特征的最新进展，并重点介绍了这些可能通过诱导移植耐受来改善同种异体移植物排斥的针对记忆 T 细胞的潜在治疗方法。
