Department of Immunology, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Curr Opin Organ Transplant. 2008 Aug;13(4):344-9. doi: 10.1097/MOT.0b013e3283061126.
The need to control donor-reactive T cell memory for successful organ transplantation is widely acknowledged. Alloreactive memory T cells are present in many human transplant recipients prior to transplantation and are less susceptible to the effects of currently used immunosuppression than naïve T cells. This review brings together recent advances in various fields of immunology that are potentially applicable for targeting memory T cells in sensitized transplant patients.
The topics of the discussion are evoked by the latest findings on immunobiology of memory T cells and include functional diversity of T-cell memory, characteristic features of memory T-cell homeostasis and signaling, costimulatory requirements of memory T cells and their susceptibility to regulation.
Despite apparent resistance of memory T cells to currently used therapies, recent findings suggest that recall responses by memory T cells can be controlled at many different levels. Use of this information may facilitate development of future tools managing T-cell memory in transplant settings.
为了成功进行器官移植，控制供体反应性 T 细胞记忆是非常必要的。在移植前，许多人类移植受者体内存在同种反应性记忆 T 细胞，它们比幼稚 T 细胞对目前使用的免疫抑制药物的作用更不敏感。本综述汇集了免疫学各个领域的最新进展，这些进展可能适用于针对致敏移植患者的记忆 T 细胞。
讨论的主题是由记忆 T 细胞免疫生物学的最新发现引起的，包括 T 细胞记忆的功能多样性、记忆 T 细胞的固有特征和信号转导、共刺激对记忆 T 细胞的要求及其对调节的敏感性。
尽管记忆 T 细胞对目前使用的治疗方法明显具有抗性，但最近的发现表明，记忆 T 细胞的回忆反应可以在许多不同水平上得到控制。利用这些信息可能有助于开发未来在移植环境中管理 T 细胞记忆的工具。
