Iwakura Shinji, Shimamoto Tetsuya, Higashiguchi Takashi, Nakase Takayuki, Shimada Kousuke, Kunimoto Hideki, Aoki Yozo
Dept. of Surgery, Hashimoto Municipal Hospital, Japan.
Gan To Kagaku Ryoho. 2012 Aug;39(8):1251-3.
A 49-year-old woman who complained of abdominal bloating and numbness in the bilateral lower limbs was diagnosed as advanced scirrhous gastric cancer with massive ascites. The biopsy specimen showed a poorly-differentiated adenocarcinoma. She was therefore treated with combined chemotherapy of tri-weekly docetaxel(40mg/m2, day 1, 22)and S-1(60mg/m2, day 1-14 with 1-week rest)for unresectable gastric cancer. After 5 courses, computed tomography showed no ascites. Furthermore, after 31 courses, the loss of ascites continued, and the thickening of the stomach walls was reduced. These findings suggested that a complete response in terms of Evaluation Criteria in Solid Tumors(RECIST)was obtained. The side effects throughout chemotherapy were Grade I anemia and Grade I alopecia. Docetaxel and S-1 chemotherapy may well be one of the effective treatments for advanced scirrhous gastric cancer.
一名49岁女性，因主诉腹胀及双侧下肢麻木，被诊断为晚期硬化型胃癌伴大量腹水。活检标本显示为低分化腺癌。因此，她接受了每三周一次的多西他赛（40mg/m²，第1天、第22天）联合S-1（60mg/m²，第1 - 14天，休息1周）治疗不可切除的胃癌。5个疗程后，计算机断层扫描显示无腹水。此外，31个疗程后，腹水持续消失，胃壁增厚减轻。这些结果表明，根据实体瘤疗效评价标准（RECIST）获得了完全缓解。整个化疗过程中的副作用为Ⅰ级贫血和Ⅰ级脱发。多西他赛联合S-1化疗很可能是晚期硬化型胃癌的有效治疗方法之一。
