Varvarenko V I, Markov V A, Kun V I, Maksimov I V, Fedorov A Iu, Krylov A L, Danilenko A M, Manchakidi G A, Karpov R S
Kardiologiia. 1990 Oct;30(10):12-5.
A total of 73 patients with myocardial infarction (MI) were included into a prospective study involving intravenous and/or intracoronary streptokinase administration. The total ejection fraction (EF) and the extent of left ventricular dys- and akinetic areas were measured by contrast ventriculography in the first 3-9 hours and 4 weeks after the onset of MI symptoms. Coronary reperfusion performed in the first 3 hours after the onset of symptoms in patients with anterior MI (n = 8) and following 3-9 hours (mean 6.6 +/- 0.89 hours) in patients with inferior MI (n = 17) significantly (p less than 0.05) reduced the extent of dys- and akinetic areas from 20.5 +/- 4.16 to 6.0 +/- 3.99 and 10.0 +/- 1.56 to 5.0 +/- 1.74%, respectively) following 4 weeks. EF significantly (p less than 0.01) increased in the former and tended to show an increase from 51.0 +/- 2.44 to 64.0 +/- 2.26% (p less than 0.1) in the latter. In patients with anterior MI (n = 19) there was a tendency to a decrease in the extent of dys- and akinetic areas from 26.0 +/- 2.85 to 17.0 +/- 3.9 (p less than 0.1) following 3-9 hours. No substantial changes were observed in the values of left ventricular dys- and akinesis and EF in patients with anterior (n = 13) and inferior (n = 16) MI without coronary reperfusion.
共有73例心肌梗死（MI）患者纳入一项前瞻性研究，该研究涉及静脉内和/或冠状动脉内注射链激酶。在MI症状发作后的最初3 - 9小时以及4周时，通过对比心室造影测量总射血分数（EF）和左心室运动障碍及运动减弱区域的范围。前壁MI患者（n = 8）在症状发作后的最初3小时内进行冠状动脉再灌注，下壁MI患者（n = 17）在症状发作后的3 - 9小时（平均6.6±0.89小时）进行冠状动脉再灌注，4周后运动障碍和运动减弱区域的范围显著（p < 0.05）缩小，分别从20.5±4.16%降至6.0±3.99%以及从10.0±1.56%降至5.0±1.74%。前壁MI患者的EF显著（p < 0.01）增加，下壁MI患者的EF则有从51.0±2.44%增至64.0±2.26%的趋势（p < 0.1）。在前壁MI患者（n = 19）中，3 - 9小时后运动障碍和运动减弱区域的范围有从26.0±2.85%降至17.0±3.9%的趋势（p < 0.1）。未进行冠状动脉再灌注的前壁MI患者（n = 13）和下壁MI患者（n = 16），其左心室运动障碍、运动减弱及EF值未观察到实质性变化。
