Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Arch Dermatol Res. 2012 Dec;304(10):787-93. doi: 10.1007/s00403-012-1282-9. Epub 2012 Aug 19.
Filaggrin gene (FLG) mutations and sensitization in patients with atopic dermatitis (AD) have been well documented. However, whether an interaction exists between these mutations and specific sensitization in AD patients is still unknown. The aim of the study was to explore the interaction between FLG mutations and specific sensitization in AD patients. A total of 249 AD outpatients were recruited in the current study. Skin prick tests were conducted to assess the patient's sensitization to specific allergens. FLG mutations were analyzed through comprehensive sequencing. Logistic regression analyses were conducted to determine the interactions between FLG mutations and sensitization present. The mean age of the patients was 3.5 years, and the mean age of onset of AD was 9.6 months. The mean SCORAD of the patients was 25.8. Fourteen types of mutations were identified in the FLG of 64 patients. A total of 24 (9.6 %) and 29 (11.6 %) cases were mutated with 3321delA and K4671X, respectively. Sensitization to at least one type of allergen was detected in 118 patients (47.4 %). Logistic regression analyses showed that FLG mutations presented an interaction with sensitization to peanut and did not interact with the other detected allergens among AD patients. Sensitization to peanut allergens would have an interaction with the mutation of K4671X and the combined mutations in FLG in patients with atopic dermatitis. However, sensitization to the other common allergens might not interact with FLG mutations in the development of atopic dermatitis.
丝聚蛋白基因（FLG）突变与特应性皮炎（AD）患者的过敏有关已得到充分证实。然而，这些突变与 AD 患者的特定过敏之间是否存在相互作用尚不清楚。本研究旨在探讨 FLG 突变与 AD 患者特定过敏之间的相互作用。共招募了 249 例 AD 门诊患者。进行皮肤点刺试验以评估患者对特定过敏原的过敏情况。通过全面测序分析 FLG 突变。采用逻辑回归分析确定 FLG 突变与存在的过敏之间的相互作用。患者的平均年龄为 3.5 岁，AD 的平均发病年龄为 9.6 个月。患者的平均 SCORAD 为 25.8。在 64 名患者的 FLG 中发现了 14 种突变。分别有 24 名（9.6%）和 29 名（11.6%）患者发生 3321delA 和 K4671X 突变。118 名患者（47.4%）至少对一种过敏原过敏。逻辑回归分析显示，FLG 突变与花生过敏存在相互作用，而与 AD 患者中检测到的其他过敏原无相互作用。花生过敏原的过敏与 K4671X 突变以及丝聚蛋白基因的联合突变在特应性皮炎患者中存在相互作用。然而，其他常见过敏原的过敏可能与特应性皮炎发病过程中的丝聚蛋白基因突变无相互作用。
