Mikhaĭlitsyn F S, Lebedeva M N, Kozyreva N P, Bolotina L A, Lychko N D
Med Parazitol (Mosk). 1990 Nov-Dec(6):52-3.
The paper presents the results of toxicological study of 44 compounds of the benzamide series synthesized during search for new anthelminthic agents. The dependence of the toxic effect of the benzamides synthesized on their structure is analysed. The experiments were carried out on white mice given the compounds under study once orally. The maximum tolerated doses of the compounds are presented. It has been found that 34 out of 44 compounds have a low toxicity and are worth of further anthelminthic screening.
本文介绍了在寻找新型驱虫剂过程中合成的44种苯甲酰胺系列化合物的毒理学研究结果。分析了所合成苯甲酰胺的毒性作用与其结构的关系。实验是对口服受试化合物的小白鼠进行的。列出了这些化合物的最大耐受剂量。已发现44种化合物中有34种毒性较低，值得进一步进行驱虫筛选。
