痴呆症进展的营养和全球指标：一项为期 12 个月的前瞻性研究。
Nutritional and global indexes of progression in dementia: a 12-month prospective study.
机构信息
Department of Medicine, DIMED, Division of Geriatrics, University of Padova, Padova, Italy.
出版信息
Am J Alzheimers Dis Other Demen. 2012 Nov;27(7):504-8. doi: 10.1177/1533317512456451. Epub 2012 Aug 17.
BACKGROUND
To assess the influence of body mass index (BMI) on the progression of dementia.
METHODS
Sixty elderly outpatients with untreated dementia followed for 12 months. All patients underwent clinical, cognitive, functional, and nutritional assessment at the baseline and after 12 months. Patients were divided into 2 groups by baseline BMI (< or ≥25 kg/m(2)).
RESULTS
Participants with a baseline BMI ≥25 kg/m(2) had significantly higher Mini-Mental State Examination (MMSE) scores (21 ± 5.1 vs 15.9 ± 5.5; P < .001), while clinical dementia rating (CDR) and multidimensional prognostic index (MPI) scores were similar in the 2 groups. After 12 months, the MMSE score decreased significantly in both groups compared to the baseline, while the CDR and MPI scores increased significantly for patients with a baseline BMI <25 kg/m(2).
CONCLUSION
A BMI cutoff of 25 kg/m(2) could be useful for identifying frail patients with dementia who will experience a more rapid global impairment, which could be assessed adequately using multidimensional evaluation tools.
背景
评估体重指数（BMI）对痴呆进展的影响。
方法
60 名未经治疗的痴呆老年门诊患者，随访 12 个月。所有患者在基线和 12 个月后均进行临床、认知、功能和营养评估。根据基线 BMI（<或≥25kg/m(2)）将患者分为 2 组。
结果
基线 BMI≥25kg/m(2)的参与者的简易精神状态检查（MMSE）评分明显更高（21±5.1 与 15.9±5.5；P<.001），而两组的临床痴呆评定量表（CDR）和多维预后指数（MPI）评分相似。12 个月后，与基线相比，两组的 MMSE 评分均明显下降，而基线 BMI<25kg/m(2)的患者的 CDR 和 MPI 评分则明显升高。
结论
BMI 截断值为 25kg/m(2)可用于识别虚弱的痴呆患者，这些患者的整体损害将更快，使用多维评估工具可以充分评估。
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