Chernyĭ A A, Lysov Iu P, Il'icheva I A, Zibrov A S, Shchelkina A K, Borisova O F, Mamaeva O K, Florent'ev V L
Mol Biol (Mosk). 1990 Sep-Oct;24(5):1399-410.
Conformational analysis of four stranded DNA helices poly(dT).poly(dA).poly(dA).poly(dT) with parallel arrangement of the identical sugar-phosphate chains connected by twofold symmetry has been performed. All possible models of symmetrical base binding were checked. By the potential energy optimization the dihedral angles and helices parameters of stable conformations of four stranded polynucleotides were calculated. The dependences of conformational energy on the base complex structure and mutual orientation of the poly(dA).and poly(dT) chains were studied. Possible biological functions of four stranded helices are discussed.
对具有通过双重对称性连接的相同糖磷酸链平行排列的四链DNA螺旋聚（dT）·聚（dA）·聚（dA）·聚（T）进行了构象分析。检查了对称碱基结合的所有可能模型。通过势能优化计算了四链多核苷酸稳定构象的二面角和螺旋参数。研究了构象能量对碱基复合物结构以及聚（dA）和聚（dT）链相互取向的依赖性。讨论了四链螺旋可能的生物学功能。
