Korinthenberg R, Schultze C
Kinderklinik, Fakultät für Klinische Medizin Mannheim der Universität, Heidelberg.
Monatsschr Kinderheilkd. 1990 Nov;138(11):759-62.
The clinical variability of pyridoxine dependent seizures is greater than mentioned in most textbooks. The seizures can start during the first days of life, or later during the first year. Frequently they are therapy-resistant, but seizure free periods of several weeks duration can be achieved with anticonvulsants in some patients. The response to the injection of pyridoxine can be delayed. A trial with daily oral administration of pyridoxine is often more suitable than a single injection.
吡哆醇依赖性癫痫的临床变异性比大多数教科书中提到的更大。癫痫发作可在出生后的头几天开始，或在出生后的第一年内稍后出现。这些发作通常对治疗有抵抗性，但在一些患者中使用抗惊厥药物可实现长达数周的无癫痫发作期。对注射吡哆醇的反应可能会延迟。每日口服吡哆醇的试验通常比单次注射更合适。
