Twu Cheryl, Han Ernest S
Department of Women's Health, Arrowhead Regional Medical Center, Colton, CA, USA;
Biologics. 2012;6:233-44. doi: 10.2147/BTT.S29356. Epub 2012 Jul 26.
Epithelial ovarian cancer is typically found in its advanced stages, where a combination of surgical debulking and platinum/taxane-based chemotherapy is recommended. Although over 70%-80% of patients achieve remission, a significant proportion develop recurrence of their disease. Additional cytotoxic chemotherapy, as well as surgery, is typically used to manage disease recurrence. Therapies that target specific pathways in cancer cells are rapidly developing in the laboratory and are increasingly being studied in patients with ovarian cancer. We review the current status of novel therapies in the management of epithelial ovarian cancer.
上皮性卵巢癌通常在晚期才被发现,此时推荐采用手术减瘤和铂类/紫杉烷类化疗相结合的治疗方法。尽管70%-80%以上的患者能够实现缓解,但仍有相当一部分患者会出现疾病复发。通常采用额外的细胞毒性化疗以及手术来控制疾病复发。针对癌细胞特定通路的疗法在实验室中正在迅速发展,并且越来越多地在卵巢癌患者中进行研究。我们综述了上皮性卵巢癌治疗中新型疗法的现状。