晚期先兆子痫胎盘中 Cyr61 和 CTGF 的相关性。

Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy.

机构信息

Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

J Perinat Med. 2012 Feb;40(2):199-200. doi: 10.1515/jpm-2011-0035.

DOI:10.1515/jpm-2011-0035

PMID:22905356

Abstract

It is thought that a shallow invasion of the maternal decidua by extravillous trophoblasts (EVT) is associated with the development of pre-eclampsia. Here, we focus on the expression of the proangiogenic proteins Cyr61 and CTGF in the human placenta during normal pregnancy compared with that in the late pre-eclamptic placenta. Cyr61 and CTGF are expressed in the extravillous trophoblast and in endothelial cells. We found the expression of Cyr61 was significantly decreased in pre-eclamptic placentas compared with matched controls. In contrast, the CTGF expression level was upregulated in pre-eclamptic placentas. There was a negative correlation between Cyr61 and CTGF. These results suggest that decreased Cyr61 and overexpressed CTGF may play a part in the development of pre-eclampsia.

摘要

人们认为，滋养层细胞外突（EVT）对母体蜕膜的浅层浸润与子痫前期的发生有关。在这里，我们重点研究了正常妊娠和晚期子痫前期胎盘组织中促血管生成蛋白 Cyr61 和 CTGF 的表达情况。Cyr61 和 CTGF 在滋养层细胞外突和内皮细胞中表达。我们发现，与匹配的对照组相比，子痫前期胎盘组织中 Cyr61 的表达显著降低。相比之下，子痫前期胎盘组织中 CTGF 的表达水平上调。Cyr61 和 CTGF 之间呈负相关。这些结果表明，Cyr61 表达降低和 CTGF 表达过度可能参与了子痫前期的发生。