Cameo Early Intervention Services, Cambridgeshire and Peterborough NHS Foundation Trust, UK.
Acta Psychiatr Scand. 2013 Mar;127(3):210-6. doi: 10.1111/acps.12000. Epub 2012 Aug 20.
To compare clinical and sociodemographic characteristics previously associated with psychosis, between individuals at high-risk for psychosis (HR) and patients experiencing a first episode psychosis (FEP), to achieve a better understanding of factors associated with psychosis.
Cross-sectional comparison of 30 individuals at HR with 30 age-gender matched FEP, presenting to an early intervention service for psychosis. Participants were followed-up for 2 years to establish the proportion of HR who made the transition into FEP.
Both groups showed similar socio-clinical characteristics, including immigration status, employment history, marital status, family history of psychotic illness, self-harm and alcohol and drug use. The HR group had a lower level of education, higher burden of trauma, earlier onset of psychiatric symptoms and a longer delay in accessing specialised services. A younger onset of symptoms was associated with a longer delay in accessing services in both groups. After a 2 year follow-up, only three (10%) of the HR group made a transition into FEP.
The similarities observed between individuals at HR and those with FEP suggest that known variables associated with psychosis may be equally prevalent in people at HR who do not develop a psychotic disorder.
比较高风险精神病个体（HR）和首发精神病患者（FEP）与精神病相关的临床和社会人口学特征，以更好地了解与精神病相关的因素。
对 30 名 HR 和 30 名年龄性别匹配的 FEP 个体进行横断面比较，这些个体均就诊于精神病早期干预服务。对参与者进行了 2 年的随访，以确定 HR 中转为 FEP 的比例。
两组的社会临床特征相似，包括移民身份、就业史、婚姻状况、精神病家族史、自残和酒精及药物使用情况。HR 组受教育程度较低，创伤负担较重，精神病症状发病较早，获得专业服务的延迟时间较长。在两组中，症状发病越早，获得服务的延迟时间越长。经过 2 年的随访，只有 3 名（10%）HR 组的个体转为 FEP。
HR 个体和 FEP 之间观察到的相似性表明，与精神病相关的已知变量可能在未发展出精神病障碍的 HR 人群中同样普遍存在。
