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Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response.

作者信息

Nabeshima T, Tohyama K, Kameyama T

机构信息

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.

出版信息

Neurosci Lett. 1990 Sep 4;117(1-2):200-6. doi: 10.1016/0304-3940(90)90144-x.

DOI:10.1016/0304-3940(90)90144-x
PMID:2290617
Abstract

The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems.

摘要

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Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response.
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引用本文的文献

1
Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice.γ-氨基丁酸能系统参与苯二氮䓬类药物诱导的小鼠被动回避学习障碍。
Psychopharmacology (Berl). 1991;105(1):22-6. doi: 10.1007/BF02316859.