Hajós F, Csillik B, Knyihár-Csillik E
Department of Anatomy and Histology, University of Veterinary Sciences, Budapest, Hungary.
Neurosci Lett. 1990 Sep 4;117(1-2):8-13. doi: 10.1016/0304-3940(90)90111-l.
Transection of a peripheral nerve induces marked increase in the glial fibrillary acidic protein (GFAP) immunoreactivity in the ipsilateral, segmentally related upper dorsal horn. Increase of GFAP immunoreaction is similar to, but not identical with, that observed after dorsal rhizotomy. If the peripheral nerve succeeds in regenerating, GFAP immunoreactivity in the upper dorsal horn returns to normal. It is concluded that the amount and distribution of GFAP is determined by transganglionic degenerative atrophy. Wallerian degeneration and regenerative proliferation of dorsal root axon terminals, respectively.
外周神经横断会导致同侧节段相关的上背角中胶质纤维酸性蛋白（GFAP）免疫反应性显著增加。GFAP免疫反应的增加与背根切断术后观察到的情况相似，但并不完全相同。如果外周神经成功再生，上背角中的GFAP免疫反应性会恢复正常。得出的结论是，GFAP的数量和分布分别由跨神经节变性萎缩、沃勒变性和背根轴突终末的再生增殖所决定。
