大鼠脊髓背根终末中的血管活性肠肽受外周神经轴浆运输的调节。
Vasoactive intestinal polypeptide in dorsal root terminals of the rat spinal cord is regulated by the axoplasmic transport in the peripheral nerve.
作者信息
Knyihár-Csillik E, Kreutzberg G W, Raivich G, Csillik B
机构信息
Department of Anatomy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
出版信息
Neurosci Lett. 1991 Sep 30;131(1):83-7. doi: 10.1016/0304-3940(91)90342-q.
Vasoactive intestinal polypeptide (VIP) immunoreactivity in the upper spinal dorsal horn is markedly increased after transection, crush or vinblastine treatment of the ipsilateral, segmentally related peripheral nerve. After regeneration of the peripheral nerve, VIP disappears from the upper dorsal horn. Transection-induced VIP increase is abolished by rhizotomy. It is concluded that the expression of VIP is restricted by factor(s) carried by retrograde axoplasmic transport to dorsal root ganglion cells.
在对同侧节段相关的周围神经进行横断、挤压或长春花碱处理后，脊髓背角上部的血管活性肠肽（VIP）免疫反应性显著增加。周围神经再生后，VIP从背角上部消失。横断诱导的VIP增加通过神经根切断术而消除。得出的结论是，VIP的表达受到通过逆行轴浆运输携带至背根神经节细胞的因子的限制。
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