Feng S W, Cao Y, Wang W G, Liu Y S, Shen X F
State Key Laboratory of Reproductive Medicine, Department of Anaesthesiology, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, China.
J Int Med Res. 2012;40(3):1099-107. doi: 10.1177/147323001204000329.
Epidural anaesthesia using chloroprocaine with or without adrenaline and lidocaine with adrenaline were compared.
Sixty parturients undergoing elective caesarean section under epidural anaesthesia were randomized to receive 3% chloroprocaine (group C), 3% chloroprocaine with adrenaline (group CA) or 2% lidocaine with adrenaline (group LA). Onset time, duration time and various maternal, fetal and neonatal parameters were monitored. Pain was assessed using a visual analogue scale.
The onset time of analgesia in group CA was similar to that in group C but was shorter than that in group LA. Duration of analgesia, loss of cold sensation and motor blockade in group CA were prolonged compared with group C, but were shorter than those in group LA. No differences in maternal, fetal or neonatal effects were seen. A higher pain score was reported in group C than in groups CA or LA at the end of surgery.
Epidural anaesthesia using chloroprocaine with adrenaline has a quick onset and moderate duration and is an attractive alternative to lidocaine and adrenaline or chloroprocaine alone for caesarean section.
比较使用含或不含肾上腺素的氯普鲁卡因以及含肾上腺素的利多卡因进行硬膜外麻醉的效果。
将60例接受硬膜外麻醉下择期剖宫产的产妇随机分为三组，分别接受3%氯普鲁卡因（C组）、3%含肾上腺素氯普鲁卡因（CA组）或2%含肾上腺素利多卡因（LA组）。监测起效时间、持续时间以及各种母体、胎儿和新生儿参数。使用视觉模拟量表评估疼痛程度。
CA组的镇痛起效时间与C组相似，但短于LA组。与C组相比，CA组的镇痛持续时间、冷觉丧失和运动阻滞时间延长，但短于LA组。在母体、胎儿或新生儿影响方面未见差异。手术结束时，C组的疼痛评分高于CA组或LA组。
使用含肾上腺素氯普鲁卡因的硬膜外麻醉起效快、持续时间适中，是剖宫产时替代利多卡因加肾上腺素或单纯氯普鲁卡因的一种有吸引力的选择。
