Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
J Cataract Refract Surg. 2012 Sep;38(9):1684-9. doi: 10.1016/j.jcrs.2012.07.008.
This retrospective observational case series describes a clinical syndrome in laser refractive surgery. Five eyes of 4 patients with noninflammatory peripheral corneal opacification in the period immediately after photorefractive keratectomy or laser in situ keratomileusis were identified and the charts abstracted. Peripheral stromal opacification, localized corneal thinning, irregular astigmatism leading to a decrease in corrected visual acuity, and gradual clearing were characteristic findings. Gradual clearing occurred without treatment in all eyes over a period of 2 weeks to 12 months. This syndrome has similarities to central toxic keratopathy but occurs in the peripheral cornea. We refer to the syndrome as toxic peripheral keratopathy, the cause of which is unknown.
本回顾性观察病例系列描述了激光屈光手术中的一种临床综合征。在准分子激光角膜切削术或激光原位角膜磨镶术后即刻，发现了 4 名患者的 5 只眼存在非炎症性周边角膜混浊，并对其图表进行了摘要。特征性表现为周边基质混浊、局部角膜变薄、导致矫正视力下降的不规则散光以及逐渐变清。所有眼睛在 2 周至 12 个月的时间内未经治疗逐渐变清。该综合征与中央毒性角膜病变相似，但发生在周边角膜。我们将该综合征称为毒性周边性角膜病变，其病因尚不清楚。
