Physical Medicine and Rehabilitation, University of Calgary, Calgary, Alberta, Canada.
Muscle Nerve. 2012 Sep;46(3):332-40. doi: 10.1002/mus.23310.
Fibrillation potentials are an accepted electrical marker of muscle denervation that occur in axonal nerve injury. Clinically, they are used to determine the type of, and prognosis for nerve injuries. The time of occurrence after nerve injury plays a critical role in clinical decision making. This study explores the evolution of the generally accepted guideline that fibrillation potentials occur 1 to 4 weeks after axonal nerve injury.
Pubmed, Ovid, and EMBASE, and current textbooks were reviewed. References were recursively followed back to the initial description of fibrillation potentials.
The majority of our understanding regarding the timing of onset of fibrillation potentials appears to arise from animal experiments in the mid-20th century.
Despite frequent use in human clinical care, published evidence for the 1 to 4 week guideline comes almost entirely from animal studies. An appreciation of this background and resulting limitations aids clinical application of this guideline.
纤颤电位是一种公认的肌肉失神经电标记，发生在轴突神经损伤中。临床上，它们用于确定神经损伤的类型和预后。神经损伤后发生的时间在临床决策中起着至关重要的作用。本研究探讨了普遍接受的纤颤电位在轴突神经损伤后 1 至 4 周发生的指南的演变。
检索了 Pubmed、Ovid 和 EMBASE，并查阅了当前的教科书。参考文献被递归地追溯到纤颤电位的最初描述。
我们对纤颤电位起始时间的大部分理解似乎都来自 20 世纪中期的动物实验。
尽管在人类临床护理中经常使用，但 1 至 4 周指南的发表证据几乎完全来自动物研究。了解这一背景和由此产生的局限性有助于临床应用这一指南。
