Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Curr Opin Obstet Gynecol. 2012 Oct;24(5):349-54. doi: 10.1097/GCO.0b013e328357628b.
Pelvic floor disorders affect women of all ages and are associated with significant economic burden and poor quality of life. Current literature suggests an association between childbirth and these disorders. In this review, we summarize recent advancements in our understanding of this association.
Vaginal childbirth appears to be strongly associated with stress urinary incontinence and pelvic organ prolapse. There is less evidence to suggest an association between vaginal delivery and overactive bladder symptoms. History of more than one perineal laceration increases the likelihood of developing prolapse. Similar association has not been established for episiotomy. Disruption or denervation of structural components of pelvic floor support system, particularly levator ani muscle complex, is associated with later development of pelvic floor disorders. Imbalance in homeostasis of connective tissue remodeling of the vaginal wall from overstretching during childbirth is another possible mechanism.
Pelvic floor disorders represent a significant health problem affecting women of all ages. Identification of potential modifiable risk factors and advancement in understanding of the underlying pathophysiology is crucial for primary and secondary prevention of these disorders and for improvement in treatment strategies.
盆底功能障碍影响各个年龄段的女性,与巨大的经济负担和较差的生活质量相关。目前的文献提示分娩与这些疾病之间存在关联。在这篇综述中,我们总结了对这种关联的最新认识进展。
阴道分娩似乎与压力性尿失禁和盆腔器官脱垂密切相关。阴道分娩与膀胱过度活动症症状之间的关联证据较少。会阴裂伤次数增加增加了脱垂的可能性。对于会阴切开术,尚未建立类似的关联。盆底支持系统结构成分的破坏或去神经支配,尤其是提肛肌复合体,与以后发生盆底功能障碍有关。阴道壁在分娩过程中过度拉伸导致的结缔组织重塑的平衡失调也是另一种可能的机制。
盆底功能障碍是一个严重影响所有年龄段女性的健康问题。确定潜在的可改变的危险因素和对潜在病理生理学的深入理解,对于这些疾病的一级和二级预防以及治疗策略的改善至关重要。