Department of Gastroenterology and Hepatology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Digestion. 2012;86(3):201-5. doi: 10.1159/000339881. Epub 2012 Aug 17.
Colonic diverticulosis is a common condition with obscure pathogenesis. Obesity, hyperlipidemia and hypertension have been demonstrated to increase the risk of complicated diverticular disease, but the impact of metabolic risk factors on the prevalence of uncomplicated diverticulosis has not been clearly determined.
The aim of the study was to examine the impact of obesity and metabolic syndrome on the prevalence of colonic diverticulosis.
This retrospective case-control study included patients aged 40-85 years who were followed up by the Institute of Medical Screening in Israel and underwent colonoscopy in 2006-2011 for indication of colorectal cancer screening. Patients with diverticulosis as detected by colonoscopy were compared to patients without diverticulosis. The comparison parameters included medical history, biometric parameters, biochemical and lipid profile.
The study included 3,175 patients. Diverticulosis was diagnosed in 17.4% of the cohort. On univariate analysis, age, male gender, BMI (continuous variable), obesity, systolic blood pressure, low-density lipoprotein cholesterol level, history of hypertension, ischemic heart disease, hypothyroidism, and absence of diabetes mellitus were associated with an increased risk of colonic diverticulosis. On multivariate analysis, advanced age, male gender, obesity (BMI >30), history of hypothyroidism and absence of diabetes mellitus were associated with an increased risk of diverticulosis. Prevalence of colonic polyps was similar in patients with and without diverticulosis.
Colonic diverticulosis was associated with age, male gender, obesity and hypothyroidism. Diabetes mellitus was associated with a decreased risk of colonic diverticulosis.
结肠憩室病是一种发病机制尚不明确的常见疾病。肥胖、高血脂和高血压已被证明会增加复杂憩室病的风险，但代谢危险因素对单纯性憩室病的患病率的影响尚未明确。
本研究旨在探讨肥胖和代谢综合征对结肠憩室病患病率的影响。
本回顾性病例对照研究纳入了在以色列医学筛查研究所接受随访且在 2006 年至 2011 年期间因结直肠癌筛查指征而行结肠镜检查的 40-85 岁患者。将结肠镜检查发现憩室病的患者与无憩室病的患者进行比较。比较参数包括病史、人体测量参数、生化和血脂谱。
本研究共纳入 3175 例患者。憩室病在队列中的检出率为 17.4%。单因素分析显示，年龄、男性、BMI（连续变量）、肥胖、收缩压、低密度脂蛋白胆固醇水平、高血压病史、缺血性心脏病、甲状腺功能减退症和无糖尿病与结肠憩室病的风险增加相关。多因素分析显示，年龄较大、男性、肥胖（BMI＞30）、甲状腺功能减退症病史和无糖尿病与憩室病的风险增加相关。有和无憩室病患者的结肠息肉患病率相似。
结肠憩室病与年龄、男性、肥胖和甲状腺功能减退症相关。糖尿病与结肠憩室病的风险降低相关。
