Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Magn Reson Med. 2013 Jul;70(1):295-300. doi: 10.1002/mrm.24460. Epub 2012 Aug 20.
MR imaging using hyperpolarized (13)C substrates has become a promising tool to study real-time cardiac-metabolism in vivo. For such fast imaging of nonrecoverable prepolarized magnetization it is important to optimize the RF-coils to obtain the best signal-to-noise ratio possible, given the required coverage. In this work, three different receiver-coil configurations were computed in pig and human models. The sensitivity maps were demonstrated in phantoms and in vivo experiments performed in pigs. Signal-to-noise ratio in the posterior heart was increased up to 80% with the best multichannel coil as expected. These new coil configurations will allow imaging of the different metabolite signals even in the posterior regions of the myocardium, which is not possible with a single-channel surface-coil.
磁共振成像使用超极化(13)C 底物已成为研究体内实时心脏代谢的有前途的工具。对于这种不可恢复的预极化磁化的快速成像,重要的是优化 RF 线圈,以获得尽可能好的信噪比,同时考虑到所需的覆盖范围。在这项工作中,在猪和人体模型中计算了三种不同的接收线圈配置。在体模和在猪体内进行的实验中证明了灵敏度图。正如预期的那样,使用最佳的多通道线圈,后心脏的信噪比提高了 80%。这些新的线圈配置将允许对不同的代谢物信号进行成像,即使在后心肌区域也是如此,这是单通道表面线圈不可能做到的。