Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, People's Republic of China.
Head Neck. 2013 Sep;35(9):1274-7. doi: 10.1002/hed.23112. Epub 2012 Aug 21.
The purpose of this study was to investigate the incidence of retropharyngeal lymph node (RPLN) metastasis and to explore the associated risk factors using CT and MRI, to direct clinical radiotherapy in hypopharyngeal carcinoma (HPC).
The CT and MRI images of 218 patients with pathologically confirmed HPC were analyzed retrospectively. The chi-square test and logistic regression were used for statistical analysis.
The incidence of RPLN metastasis in HPC was 17.0%, and the highest rate of 36.4% was found in pharyngeal wall carcinoma. None of the patients with N0 classification exhibited RPLN metastasis. Univariate and multivariate analyses demonstrated that primary tumor subsites, bilateral cervical lymph node metastasis, the number and size of cervical lymph nodes, and level V metastasis were significantly associated with RPLN metastasis.
Our findings demonstrated that primary carcinoma subsites and multiple metastatic cervical lymph nodes are the principal risk factors for RPLN metastasis.
本研究旨在通过 CT 和 MRI 来探究下咽癌（HPC）后咽部淋巴结（RPLN）转移的发生率及其相关危险因素，以指导临床对 HPC 进行放射治疗。
回顾性分析 218 例经病理证实的 HPC 患者的 CT 和 MRI 图像。采用卡方检验和逻辑回归进行统计学分析。
HPC 的 RPLN 转移发生率为 17.0%，其中咽壁癌的转移率最高，为 36.4%。N0 分类的患者均无 RPLN 转移。单因素和多因素分析表明，原发肿瘤部位、双侧颈部淋巴结转移、颈部淋巴结数量和大小以及 V 区转移与 RPLN 转移显著相关。
本研究结果表明，原发癌部位和多个转移性颈部淋巴结是 RPLN 转移的主要危险因素。
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