Hawe P, Higgins G
Patient Educ Couns. 1990 Oct;16(2):151-60. doi: 10.1016/0738-3991(90)90090-8.
We report the evaluation of a pharmacist-led medication education program for the elderly. The program consisted of a single group-based education session followed by individual pre-discharge counseling. Patients also received an individual medication record card. The study design was a nonrandomised trial. Patients in the control group received a "dummy" intervention conducted on alternate months to the medication program. Drug compliance was assessed by interviewer-administered questionnaire in the patients' homes at 1 and 3 months post-discharge. The main outcome factor of interest was severe noncompliance with essential medications. This meant taking 80% or less or conversely 120% or more of those medications prescribed for the control of the patient's medical condition. At 1 and 3 months post-discharge, no effect of the program was detected. However, among the sub-group of patients taking four drugs or more the effect of the program was evident at 3 months post-discharge. Among this group at 3 months post-discharge, 55% of control group patients were severely noncompliant with essential medications as compared to 32% of the education group (a difference of 23%, 95% confidence interval 4-42%). This effect was not accounted for by possible confounding factors such as age, sex, number of medications and the patient's living arrangements.
我们报告了一项针对老年人的由药剂师主导的药物治疗教育项目的评估情况。该项目包括一次基于小组的教育课程，随后是出院前的个体咨询。患者还收到了一份个人用药记录卡。研究设计为非随机试验。对照组患者接受与药物治疗项目交替进行的“虚拟”干预。出院后1个月和3个月，通过访员在患者家中进行问卷调查来评估药物依从性。主要关注的结果因素是对基本药物的严重不依从。这意味着服用规定用于控制患者病情药物的80%或更少，或者相反，服用120%或更多。出院后1个月和3个月时，未检测到该项目有效果。然而，在服用四种或更多药物的患者亚组中，该项目的效果在出院后3个月时很明显。在出院后3个月的这个组中，对照组55%的患者对基本药物严重不依从，而教育组为32%（相差23%，95%置信区间4%-42%）。这种效果不能用年龄、性别、用药数量和患者生活安排等可能的混杂因素来解释。
