Krejci Charlene B, Bissada Nabil F
Department of Periodontics, Case Western Reserve University, School of Dental Medicine, Cleveland, OH, USA.
Oral Health Prev Dent. 2012;10(1):83-92.
To examine the literature with respect to periodontitis and issues specific to women's health, namely, hormonal changes, adverse pregnancy outcomes and osteoporosis.
The literature was evaluated to review reported associations between periodontitis and genderspecific issues, namely, hormonal changes, adverse pregnancy outcomes and osteoporosis.
Collectively, the literature provided a large body of evidence that supports various associations between periodontitis and hormonal changes, adverse pregnancy outcomes and osteoporosis; however, certain shortcomings were noted with respect to biases involving definitions, sample sizes and confounding variables. Specific cause and effect relationships could not be delineated at this time and neither could definitive treatment interventions.
Future research must include randomised controlled trials with consistent definitions, adequate controls and sufficiently large sample sizes in order to clarify specific associations, identify cause and effect relationships, define treatment options and determine treatment interventions which will lessen the untoward effects on the at-risk populations.
研究关于牙周炎以及女性健康特定问题的文献，这些问题包括激素变化、不良妊娠结局和骨质疏松症。
对文献进行评估，以回顾所报道的牙周炎与性别特定问题之间的关联，这些问题包括激素变化、不良妊娠结局和骨质疏松症。
总体而言，文献提供了大量证据支持牙周炎与激素变化、不良妊娠结局和骨质疏松症之间的各种关联；然而，在涉及定义、样本量和混杂变量的偏倚方面存在某些不足之处。目前尚无法确定具体的因果关系，也无法确定明确的治疗干预措施。
未来的研究必须包括随机对照试验，要有一致的定义、适当的对照和足够大的样本量，以便阐明具体关联、确定因果关系、定义治疗选择并确定能够减轻对高危人群不良影响的治疗干预措施。
