Department of Pathology, Diósgyori Vasgyári Hospital, Miskolc, Hungary.
Int J Lab Hematol. 2013 Feb;35(1):88-91. doi: 10.1111/j.1751-553X.2012.01465.x. Epub 2012 Aug 22.
Blood coagulation factor XIII (FXIII) plays a key role in the protection of fibrin clot against fibrinolysis, in the cross-linking of fibrin and its mechanical strength. The role of the FXIII-A subunit Val34Leu polymorphism with fatal primary intracerebral hemorrhages (PICH) has not been studied. We evaluated retrospectively the prevalence of this polymorphism in stroke patients with fatal PICH and population control matched for age and gender. The prevalence of this polymorphism was determined for patients with fatal PICH (n = 98, female/male: 41/57) and controls. DNA was obtained from peripheral white blood cells in case of controls and from paraffin-embedded tissue sections in case of fatal PICH. The odds for increasing the risk of PICH against the control group were 5.429, 3.286, and 7.661 for total, female, and male patients, respectively. The Leu34Leu homozygous variant of the FXIII Val34Leu polymorphism significantly increased the risk of fatal PICH stroke in men.
凝血因子 XIII（FXIII）在保护纤维蛋白凝块不受纤维蛋白溶解、交联纤维蛋白及其机械强度方面发挥着关键作用。FXIII-A 亚单位 Val34Leu 多态性与致命性原发性脑出血（PICH）的作用尚未得到研究。我们回顾性评估了致命性 PICH 中风患者和年龄、性别匹配的人群对照中这种多态性的流行情况。确定了致命性 PICH 患者（n=98，女性/男性：41/57）和对照组中这种多态性的流行情况。在对照组中，从外周白细胞中获得 DNA，在致命性 PICH 的情况下，从石蜡包埋组织切片中获得 DNA。与对照组相比，总患者、女性患者和男性患者发生 PICH 的风险增加的几率分别为 5.429、3.286 和 7.661。FXIII Val34Leu 多态性的 Leu34Leu 纯合变体显著增加了男性致命性 PICH 中风的风险。
