Chandra Rai Ramesh, Dwivedi Ved Prakash, Chatterjee Samit, Raghava Prasad Durbaka Vijaya, Das Gobardhan
Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Microbes Infect. 2012 Nov;14(13):1220-6. doi: 10.1016/j.micinf.2012.07.019. Epub 2012 Aug 9.
T helper (Th) 1 and 17 cells play important roles in host protective responses against tuberculosis. Early Secretory Antigenic Target 6; a Region of Difference 1 (RD1) encoded protein, mounts Th17-responses in the lung. Therefore, lack of RD-1 region makes Bacillus Calmette-Guérin (BCG) less vaccine efficacious than parent strains.
辅助性T细胞（Th）1和17细胞在宿主抗结核保护性反应中发挥重要作用。早期分泌性抗原靶标6；差异区域1（RD1）编码蛋白在肺部引发Th17反应。因此，缺乏RD-1区域使得卡介苗（BCG）的疫苗效力低于亲本菌株。
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