P2 受体与免疫。
P2 receptors and immunity.
机构信息
Institut de Biochimie et Biophysique Moléculaire et Cellulaire, CNRS UMR 8619, Université Paris Sud, 91405 Orsay Cedex, France.
出版信息
Microbes Infect. 2012 Nov;14(14):1254-62. doi: 10.1016/j.micinf.2012.07.006. Epub 2012 Aug 13.
Abstract
Immune cells express receptors for extracellular nucleotides named P2 receptors. P2 receptors transduce signals delivered by nucleotides present in the extracellular environment. Accruing evidence shows that purinergic signalling has a profound effect on multiple immune cell responses such as T lymphocyte proliferation, chemotaxis, cytokine release, phagocytosis, Ag presentation and cytotoxicity. This makes P2 receptors an attractive target for the therapy of immuno-mediated disease and cancer.
摘要
免疫细胞表达细胞外核苷酸的受体，称为 P2 受体。P2 受体转导细胞外环境中存在的核苷酸传递的信号。越来越多的证据表明，嘌呤能信号对多种免疫细胞反应有深远的影响，如 T 淋巴细胞增殖、趋化性、细胞因子释放、吞噬作用、抗原呈递和细胞毒性。这使得 P2 受体成为免疫介导疾病和癌症治疗的有吸引力的靶点。
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Nat Med. 2012 Mar 18;18(4):600-4. doi: 10.1038/nm.2679.
2
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Science. 2011 Dec 16;334(6062):1573-7. doi: 10.1126/science.1208347.
3
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