[采用加权积分法估算PET测量中三室模型的三个速率常数——估算误差模拟]

[Estimation of 3 rate constants of the 3 compartments model in PET measurement by a weighted integral method--simulation of estimation errors].

作者信息

Inoue H, Morikawa H, Iida H, Kanno I, Miura S, Okuyama D, Uemura K

机构信息

Department of Electronic Engineering, Mining College, Akita University, Japan.

出版信息

Radioisotopes. 1990 Dec;39(12):557-64. doi: 10.3769/radioisotopes.39.12_557.

DOI:10.3769/radioisotopes.39.12_557

PMID:2290995

Abstract

A simulation study to evaluate the errors in rate constants of the three compartment model using the weighted integral method was performed. Ten combinations of 7 kinds of weight functions, the errors were tested in 18F fluorodeoxyglucose (18FDG) study. The error factors arising in PET measurement were statistical noise, cerebral blood volume, time shift and scanning time of PET measurement. Errors in each rate constant were within the range of 10 percent and those in k1k3/(k2+k3) within 1 percent. The weighted integral method was confirmed to be a faster method than the conventional least squares method within a reasonable error range.

摘要

进行了一项模拟研究，以使用加权积分法评估三室模型速率常数的误差。对7种权重函数的10种组合，在18F氟脱氧葡萄糖（18FDG）研究中测试了误差。PET测量中出现的误差因素包括统计噪声、脑血容量、时间偏移和PET测量的扫描时间。每个速率常数的误差在10%范围内，k1k3/(k2 + k3)的误差在1%以内。在合理的误差范围内，加权积分法被证实是一种比传统最小二乘法更快的方法。