对西孟加拉邦一家三级保健医院出生的婴儿进行葡萄糖-6-磷酸脱氢酶筛查。

Glucose-6-phosphate dehydrogenase screening of babies born in a tertiary care hospital in West Bengal.

机构信息

Department of Community Medicine, IPGME and R, Kolkata, India.

出版信息

Indian J Public Health. 2012 Apr-Jun;56(2):146-8. doi: 10.4103/0019-557X.99908.

Abstract

About 400 million individuals worldwide have been affected by the inherited disorder of glucose-6-phosphate dehydrogenase (G6PD) deficiency that predisposes individuals to neonatal jaundice or hemolytic crisis due to drugs or infections. A descriptive observational study with longitudinal design was undertaken among 109 live newborns, delivered in labor room of IPGME and R, Kolkata during the period from June to August 2009. An objective of the study was to estimate the occurrence of G6PD deficiency among newborns and its association with different socio-demographic, clinical and gestational characteristics. 14.68% newborns were found G6PD deficient. This occurrence was not significantly related to gender, religion and ethnicity, consanguineous marriage of the parents, gestational age and birth weight of the baby. Development of severe jaundice (total serum bilirubin >15 mg/dl) was found 23.8% among G6PD deficient babies and 12.5% among non-G6PD deficient. This difference was statistically not significant.

摘要

全世界约有 4 亿人受到葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症的遗传影响，这种疾病使个体易因药物或感染而发生新生儿黄疸或溶血性危机。本研究为描述性观察研究，采用纵向设计，于 2009 年 6 月至 8 月在加尔各答的 IPGME 和 R 的产房对 109 例活产新生儿进行研究。本研究的目的是评估新生儿 G6PD 缺乏症的发生率及其与不同社会人口学、临床和妊娠特征的关系。14.68%的新生儿被发现存在 G6PD 缺乏症。这种发生率与新生儿的性别、宗教和种族、父母的近亲结婚、胎龄和出生体重均无显著相关性。在 G6PD 缺乏症婴儿中，严重黄疸（总血清胆红素>15mg/dl）的发生率为 23.8%，而非 G6PD 缺乏症婴儿中为 12.5%。这种差异无统计学意义。