Ashkenazi S, Mimouni F, Merlob P, Reisner S H
Isr J Med Sci. 1983 Dec;19(12):1056-8.
Eight hundred preterm (PT) and low-birth-weight (LBW) infants, born during a period of 33 months, were examined for erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity. Each of 17 infants with G6PD deficiency was compared with the next PT or LBW infant born with normal enzyme activity. The groups were similar with respect to gestational age, birth weight, maximal weight loss, breast or formula feeding and the use of oxytocin during labor. Peak bilirubin levels were significantly higher in G6PD-deficient PT and LBW infants (11.7 +/- 1.4 vs. 9.5 +/- 2.1 mg/dl, P less than 0.001). There were no signs of frank hemolysis, and none of the patients underwent exchange transfusion. Early jaundice and the use of phototherapy were somewhat more frequent among the G6PD-deficient group, but not significantly so. It is suggested that PT and LBW infants born to parents of Asian or North African origin be routinely screened for erythrocyte G6PD activity and monitored for possible jaundice.
在33个月的时间段内出生的800名早产儿（PT）和低体重儿（LBW）接受了红细胞葡萄糖-6-磷酸脱氢酶（G6PD）活性检测。将17名G6PD缺乏的婴儿与下一个出生时酶活性正常的PT或LBW婴儿进行了对比。两组在胎龄、出生体重、最大体重减轻、母乳喂养或配方奶喂养以及分娩期间催产素的使用方面相似。G6PD缺乏的PT和LBW婴儿的胆红素峰值水平显著更高（11.7±1.4对9.5±2.1mg/dl，P<0.001）。没有明显溶血的迹象，且没有患者接受换血治疗。G6PD缺乏组早期黄疸和光疗的使用略为频繁，但差异不显著。建议对亚洲或北非裔父母所生的PT和LBW婴儿常规筛查红细胞G6PD活性，并监测是否可能出现黄疸。
